Ochratoxin A-induced cytotoxicity in liver (HepG2) cells: Impact of serum concentration, dietary antioxidants and glutathione-modulating compounds*
نویسندگان
چکیده
(1)Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel (2)Institute of Animal Nutrition and Physiology, Christian-Albrechts-University Kiel Ochratoxin A-induced cytotoxicity in liver (HepG2) cells: Impact of serum concentration, dietary antioxidants and glutathione-modulating compounds* Christine Bösch-Saadatmandi(1), Christoph Hundhausen(1), Laia Jofre-Monseny(1), Ralf Blank(2), Siegfried Wolffram(2), Gerald Rimbach(1)
منابع مشابه
Exploring the Protective Effects of Abrus precatorius in HepG2 and N-Nitrosodiethylamine-Induced Hepatocellular Carcinoma in Swiss Albino Rats
This study was designed to explore the protective effects of Abrus precatorius L. (Leguminosae) (AP) in HepG2 cells and N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in Swiss albino rats. The effects of aqueous/ethanolic (50%) extract of AP on hepatic markers, haematological and histopathological parameters, and antioxidant enzymes were evaluated in NDEA ...
متن کاملToxicity Effect of Hydro-Alcoholic Extract of Pistachio Hull and Its Liposomal Form on Liver Cancer Cells (HepG2)
Background and Objectives: Pistachio skin is rich in phenolic compounds and an inexpensive source of antioxidants, which can be a good option for combating cancer cells. The aim of this study was to determine the potential of pistacia vera hydroalcoholic extract and its liposomal form as a potential cytotoxic agent in HepG2 cell line, which is related to human liver cancer. Materials and Metho...
متن کاملEffects of methanolic extracts of Epilobium parviflorum on growth and function of human liver cells HepG2
Introduction: Epilobium parviflorum, the willow-herb, extracts contain strong antioxidant compounds and inhibit few types of cancer cell. This study investigates for the first time the effect of its extracts on the growth of human liver cells HepG2, also under oxidative stress. Materials and Methods: Methanolic extract of roots, shoots and flowers was prepared separately. Cell viability was ass...
متن کاملNanoceria Attenuated High Glucose-Induced Oxidative Damage in HepG2 Cells
OBJECTIVE Hyperglycemia, a common metabolic disorder in diabetes, can lead to oxidative damage. The use of antioxidants can benefit the control and prevention of diabetes side effects. This study aims to evaluate the effect of nanoceria particles, as an antioxidant, on glucose induced cytotoxicity, reactive oxygen species (ROS), lipid peroxidation (LPO) and glutathione (GSH) content in a human ...
متن کاملCytotoxicity of Subtoxic AgNP in Human Hepatoma Cell Line (HepG2) after Long-Term Exposure
Background: We aimed at evaluating the toxicity effects of low (subtoxic) concentrations of silver nanoparticles (AgNP, 5-10 nm) in human hepatoblastoma (HepG2) cell line after and during a period of about one month. Methods: XTT and MTT assays were used to draw a dose-response curve IC50 (half maximal inhibitory concentration) value of the AgNP on HepG2 cells was calculated to be 2.75-3.0 mg/l...
متن کامل